Small-size specific-pathogen-free-pig conveying tool for testing

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ABSTRACT:The utility model relates to a small-size specific-pathogen-free-pig conveying tool for testing and belongs to the technical field of specific-pathogen-free-animal equipment. The tool comprises a box body and a buffering chamber which is arranged on the outer side of the box body and is tightly and integrally connected with the box body. A gas filtering device is arranged at the top of the box body. A water supply device is arranged on one side in the box body. An observing window is arranged on the other side in the box body. A sewage discharging device is arranged on the bottom of the box body. Gas exhaust devices are arranged on the two sides of the inner wall of the box body. The gas exhaust devices are placed above the sewage discharging device. An automatic door is arranged between the box body and the buffering chamber. The box body and the buffering chamber are communicated when the automatic door is opened automatically. An outer door is arranged on one side, far away from the box body, of the buffering chamber. The tool can solve the problem that specific-pathogen-free (SPF) pigs are not infected by pathogenic microorganisms, so that the SPF pigs are turned into non-SPF pigs.

Technical Field:The utility model relates to a test with a small specific pathogen free pig transport equipment, belonging to no particular technical field of animal pathogen equipment.

Background:Specific Pathogen Free (Specific Pathogen Free, SPF) pigs by Dr. Yong United States in 1951, according to the production of disease-free animal production test principle established SPF pigs. SPF pigs as experimental animals, generally require growth in the barrier system or isolators, no international, domestic (especially domestic) predominant pathogen swine infectious diseases.

Special value :SPF pigs that: no major infectious diseases, no vertical infectious diseases, no pig comorbidity, no experimental study microbes that might cause interference. SPF pigs have a keen sensitivity to a variety of pathogens, and consistent response and good reproducibility. Experimental results are accurate and reliable. Swine research conducted through the establishment of various pathogens specific pathogen free pig with a small artificial infection model, may exclude non-interference study pathogens, it is beneficial for diseases, changes in the analysis, biological medicine, animal husbandry and veterinary applications engaged a high level of scientific research and a variety of human and animal biological products, identified by the indispensable and irreplaceable experimental animals and raw materials, its quality is directly related to the above areas of health research reliability, accuracy, and the masses. Whether the use of SPF pig has become an important indicator to measure the experimental accuracy.

With the rise of the animal protection movement, restrictions on international animal protection organizations in experimental animals become more stringent, most developed countries have developed a set of better animal management laws and regulations, "31?" 0 ^ (111 ( ^ 1? India 1 & (^, Refine) principle gradually promote the use of non-human primates and dogs and other higher animals is restricted, gradually replaced by food-producing animals such as pigs. Since 1966, the amount of pigs as test animals In fourth place all kinds of experimental animal usage.

Currently, the United States and Europe, most established SPF breeding swine production system, is now able to supply to the market experiment in SPF miniature pigs. Such as Germany Gottingen miniature pigs, 1984 has been sold to many countries and regions, and subsequently set up a Ellegaader multinational with a `two SPF breeding farms, specialized in experimental miniature pig research, development and supply.

In accordance with the standard of SPF pig "SPF swine pathogen control and monitoring" (GB / T22914-2008) refers to laboratory testing without pseudorabies, PRRS virus, transmissible gastroenteritis virus, porcine epidemic diarrhea virus, swine fever, Brucella suis, swine Pasteurella multocida, Mycoplasma hyopneumoniae, infectious pleuropneumonia, swine dysentery, lice and mites and other 12 kinds of pathogens of pigs. One such as PRRS virus, swine mycoplasma pneumonia and other pathogens can be airborne.

SPF Pigs can be applied to the following aspects: (1) swine disease research (an artificial infection model) to exclude non-research interference pathogens. As artificial experimental infection, it is beneficial for diseases, change analysis. The test results provide a reliable scientific basis for control measures. (4) the study of human disease model (2) human, animal identification of a variety of manufacturing and vaccine quality live vaccines (3) nutrition, embryology, pathology research.

The PwC report shows that in 2010 China CRO market is nearly 17 billion yuan, and is growing at 30% growth rate. China has surpassed India to become Asia's first choice for R & D outsourcing. In new drug R & D outsourcing services market in pre-clinical studies occupy 46% market share. Where the pharmacokinetics, pharmacology and toxicology and Phase I clinical study holds the largest share of 32%, followed by studies in animal models (Research Model Service, RMS) holds 9%. These studies require high-quality experimental animals for research material. However, China's SPF pigs have not formed industrialization, resulting in its lack of application in medical biology, application advantage is not prominent characteristics of the application is not obvious, not only limits the application of SPF pigs themselves, limits the pharmaceutical outsourcing services and development of other biomedical field, not far from the needs of the market supply.