Group toxicology analyzer

Medicilon’s toxicology department has professional teams with rich experience in toxicology studies. We offer high-quality data and rapid turnaround period to support drug discovery and development. Our toxicological studies are conducted in various animal species. The toxicological evaluation from dose design, in-life studies to histology and pathology testing along with toxicokinetics studies are all compliant with GLP or NON-GLP standards. Our study platform is certified as one of the Shanghai Public Service Research Platforms.Email:marketing@medicilon.com.cn Web:www.medicilon.com.

Technical Field:The patent belongs to the analysis in the field test instrument, to a group toxicological analysis instrument. The device is capable of automatic online complex system of separation of the constituent compound identification and evaluation of biological activity, toxicology studies in terms of environmental pollutants, metabolite compound research, toxicity evaluation of industrial products, drug screening and analysis of active ingredients, which are widely application prospects.

Background:Currently, the composite effect of biological activity and evaluate complex system of constituent compounds typically involves three steps: (l) depending on the physical or chemical properties of the composite pollutants into multiple components. Toxicity by bioassay method for identifying the components, to identify the components having biological activity; (2) of the biologically active component further separation, screening the specific components or compounds having biological activity, and its qualitative and Quantitative analysis; (3) Integrated biometric and chemical analysis results, the toxicity factor quantitative and correlation analysis. Such programs operate very

Cumbersome, and more for offline operation, not only time consuming, operator proficiency and experience requirements are also higher, different operators may yield different results. Therefore, we developed the "Group of Toxicology points off the meter", which is capable of complete line of high-throughput sample separation, component analysis and analysis of biological activity of spotting a relatively complex three-part work, greatly reducing the operator's reliance, while improving the reliability and efficiency of work related to the evaluation results, s former home and abroad there are no comparable specialized equipment.

DISCLOSURE:The purpose of this invention patent is to provide a group toxicology analyzer, which is capable of high-throughput online complex system of separation of the components of the compound, spotting three-part composition analysis and evaluation of the biological activity of relatively complex work.

Patented the invention has been achieved by the following technical solutions. It consists of six major modules: module fractionation l, fraction collection module 2, the robot arm 3, a solution processing platform 4, compound 5 was measured module, a data processing and control system 6. Wherein component collection module 2, 3 and the robot arm was treated platform 4 is placed in the clean bench 7, to maintain a sterile environment. 8 is a special tube rack (12.8cm long "6cm width), its size and the same common 96, easy to automate, test tube rack 8 placed 10mL tubes. 9 is a storage pallet for storing backup or handle 96 to be placed test tube rack 8. L chromatographic separation module by the high-pressure pump, column preparation, analysis column metered valve, switching wide composition, mainly to complete the separation of various compounds. Separation module 1 and collection module via Teflon tubing connection between two collection module 2 components of the solution was collected by a robotic arm to transfer solution processing module 4 spotting. Compound measuring module 5 by the triple quadrupole tandem mass spectrometry (MS / MS) and liquid chromatography detector UV detector composed of pipe and connected by a chromatographic separation module l PEEK (poly ether ketone), passing between the two detectors diverter valve connection, the solution may follow a certain proportion into the two detectors. Separation module 1, fraction collection module 2, the robot arm 3, solution processing platform 4 and 5 by 6 compound measuring module controls the data processing and control system, the entire system

3 system can automatically complete the operation in accordance with a predetermined program, the data obtained by the data processing and control system for recording and processing 6.

Advantages of this invention patent is: (1) can be completed online high throughput sample separation, spotting three-part composition analysis and biological evaluation of the operation, greatly improved the efficiency of the tedious, but also avoids the manual operation brought error; (2) the components of a computer-controlled "smart" collection and spotting, can be made without a significant increase in the number of bioassay samples, the realization evaluate the interaction between compound; (3) The entire device consists of different modules composition, can be a variety of combinations to achieve a variety of complex functions. Determination of the separation module 1 and module 5 can also be combined and configured as required. (4) The fraction collector module 2, 3, and was treated with a robotic arm placed in a laminar flow hood platform 4, the entire operation in a sterile environment Bu complete biological activity evaluation results are more reliable.