Method for breeding experimental macaca mulatta

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The invention provides a method for breeding experimental macaca mulatta. The mode of female money single-cage raising and regular mating is adopted in the mating period, the mode that infant monkeys and a female monkey are raised in a concentrated mode in the lactation period and an adult male monkey is isolated is adopted, the monkey group fighting problem is effectively solved, the infant monkeys are raised in a single-breeding monkey cage in the ablactation period, the breeding quality is further improved, and the health condition of the macaca mulatta can be discovered and managed in time. The breeding rate and the pregnancy rate of the macaca mulatta are further improved, the phenomenon that the female monkey of the right age is infertile in the breeding period is greatly reduced, the oestrus, mating and farrowing activities of personal macaca mulatta can be observed conveniently, and the health condition of the macaca mulatta can be discovered and managed in time. According to the method, overall comprehensive breeding management is combined with rich and reasonable breeding equipment, and thus the yield and the quality of the experimental macaca mulatta are greatly improved.

said the monkey (Macaca mulatta) belong Primates (Primates) Cercopithecidae (Eereopithecidae) called Monkey (Macaca) animals, as "Endangered Species of Wild Fauna and Flora International Trade Convention (CITES)" Appendix II species.

macaque as human kinship with the closest species of non-human primates (Nonhuman Primates, NHP) and human genetic material more than 95% homology, and the organizational structure, immunity, physiology and metabolism respect human height approximation, which has a clear comparative advantage in biomedical research traitor, a traitor and basic research has become an ideal animal model to solve problems of human health and disease in pre-clinical research traitor. China SFDA and FDA clearly requires more than two types of new drugs in clinical trials before, must obtain reliable data on NHP animal experiments. China also states: "The neurological, psychiatric, anesthesia type, biological products category, appliances and other family planning medicines must be approved by NHP animal experiments approved before entering clinical trials." At present, with AIDS, Parkinson's, cancer establish lung damage, liver damage and other long-standing human ills NHP disease models, as well as related drugs especially preclinical study based evaluation, NHP application is not around the past Hom. NHP proteins in particular the importance of new drugs biological products for drug development is evident.

monkeys, as the Chinese national animal protection, population traitor applied research in experimental animals has been increasing year by year in recent years, but mainly due to the current international breeding cynomolgus monkeys mainly just for monkeys reared in infancy, mainly from the wild, wild monkey experiment with one hand because there is no clear genetic background, a clear and stable microbial biological characteristics of the state, so the reliability of the experimental results is doubtful; the other hand, wild monkeys to capture inevitably result in excessive depletion of wildlife resources, and the development of human civilization very inconsistent.

The experimental primates China attaches great importance to the same resource, macaque experiments included in the "national" five "animals platform construction" project to provide support conditions for the development of national strategic emerging industries. Ministry formulated the "primate laboratory animal husbandry management practices and quality standards", set up a "primate laboratory animal industry strategic alliance." It is because of the great value of the experimental monkeys, Western countries (including the country) will be listed as a strategic resource research. Some experts even predict that the future of competition in the pharmaceutical industry may be competitive experiments in primates resources.

Thus genetic differences to understand the genetic background of experimental monkeys and populations through existing genetic records management system to adjust the macaque experiments, genetic information management, the establishment of experimental animals macaque detailed individual files and pedigree systems, establish an effective, accurate and reliable, quick and easy monitoring of genetic background, while establishing a sound feeding, breeding standard operating procedures, epidemic prevention system and disease prevention and control program for the cultivation of macaque experimental populations to provide technical support is particularly important.

According to 2009 statistics, the breeding stock of 21 million Chinese monkeys, of which nearly 30,000 macaques. According to 2011 statistics, nearly a decade of international market demand for the experimental monkeys annual growth rate of over 20%. In 2010, global demand macaque experiment nearly 200,000, while the amount of global experimental macaque breeding year only 13 million only, the market demand gap is very obvious. According to the relevant forecast shows the next five years (2012-2016), the global market for medical experiments macaque demand will maintain strong growth momentum in 2016 demand will reach 25-30 million.

For the purposes of China's domestic demand, along with increasing levels of Chinese science and technology, and the comparative advantages of various costs, large international pharmaceutical companies and research institutions have the R & D center traitor into China, or the relevant R & D tasks Outsourcing. This is certainly experimental animals for China, but also certainly to the global development of animal experiments. Will effectively promote domestic monkeys and usage patterns of animals, in the foreseeable time frame will be a rising trend.

It has been reported worldwide each year for research Macaca animals only up to 10 million, China needs thousands every year. Although some countries have invested heavily in the establishment of a number of monkeys games, but still need to produce importers from China and Vietnam, a lot of rhesus macaques.

keeping the size and needs of Chinese monkeys gradually expanded, but because of long-term lack of standardized management, leading to disorderly competition between industries, violations of law, underdevelopment and low quality animal series of problems, not only cause for conservation a huge risk, but also damaged China's international reputation.